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Parents notice their 7-month-old son has troubling physical impairments, then begins violently harming himself, culminating in a horrifying incident where the child bites off his own lower lip; he is later diagnosed with the genetic condition Lesch-Nyhan syndrome. A woman traveling the world starts experiencing unusual back pain and tingling in her feet that rapidly develops into a spreading paralysis; following the successful use of plasmapheresis, the cause of the dangerous condition is identified as Devic's disease, an inflammation of the spinal cord.